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Discovering Whole Gene Biomarkers

Accurately diagnose with all mutations that cause a disease

Accurate diagnostics with precision biomarkers

Genetic biomarkers are particularly useful for diagnoses and therapeutics. However, most approved drugs have a single variant biomarker. Heligenics offers whole gene biomarkers, where diagnosis can be based upon all variants with similar activity to an established biomarker.

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Whole gene biomarkers examine all the mutations in a gene rather than a single mutation. This is a natural conceptual expansion of what is already in common clinical practice.

Five Facts

  • Steady growth in genetic biomarkers over the last decade

  • There are 100s of genetic biomarkers

  • Genes have many variants with the same activity as known biomarkers

  • Whole gene biomarkers expand the number of customers eligible for a drug

  • Drug resistance mutations for a whole gene are useful

Why use one genotype when you can use a  whole gene biomarker?

Treatments  based on one genetic marker have medical advantages

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  • 46% of total recent approvals

  • One mutation as a biomarker

From “The Personalized Medicine Report: 2017 Opportunity, Challenges, and the Future”.
http://www.personalizedmedicinecoalition.org

One Size Does Not Fit All 
Percentage of the patient population for which a particular drug is NOT effective

         Anti-Depressants (SSRIs)            38%                     

Asthma Drugs                     40%

Diabetes Drugs                     43% 

Arthritis Drugs                       50% 

Alsheimer’s Drugs                 70%

Cancer Drugs                         75%

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Whole Gene Biomarker 
Example of patients with single mutation biomarker identified versus using MEGA-Map™ whole gene biomarker panel

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Single Mutation

Biomarker 

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MEGA-Map™ Whole Gene Biomarker 

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Disease, but lack Single
Mutation Biomarker

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Disease with Whole Gene
Biomarker

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Disease with Single Mutation
Biomarker

Join the functional genome revolution!
Reach out today for more information.
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