Publications

High-throughput characterization of 5886 HER2 variants identifies 112 new in cellulo gain-of-function mutations.

Giacoletto CJ, Valente LJ, Brown L, Patterson S, Gokhale R, Mockus SM, Grody WW, Deng H-W, Rotter JI, Schiller MR.

Genomics (2025) 117:111118

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Central Dogma Cycle and Network: A Model for Cell Memory

Schiller MR

arXiv (2025) 2506:16374

https://doi.org/10.48550/arXiv.2506.16374

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New Gain-of-Function Mutations Prioritize Mechanisms of HER2 Activation

Giacoletto CJ, Valente LJ, Brown L, Patterson S, Gokhale R, Mockus SM, Grody WW, Deng H-W, Rotter JI, Schiller MR.

MedRxiv (2025)

https://doi.org/10.1101/2025.03.03.25323043; PMID: 40093211

 

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The Gigaassay: A Combined High Throughput and Highly Accurate Platform for Variant Classification

Giacoletto CJ, Valente LJ, Brown L, Patterson S, Gokhale R, Mockus SM, Grody WW, Deng H-W, Rotter JI, Schiller MR.

SSRN (2025) 

 http://dx.doi.org/10.2139/ssrn.5251898

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Synonymous Variants of Uncertain Silence

Giacoletto CJ, Rotter JI, Grody WW, Schiller MR.

Int. J. Mol. Sci. (2023) 24: 10556

https://doi.org/10.3390/ijms241310556; PMID: 37445732

 

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The History and Conceptual Framework of Assays and Screens.

Giacoletto CJ, Schiller MR.

Bioessays (2023) 45:e2200191

https://doi.org/10.1002/bies.202200191; PMID: 36789580

 

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Accurate Prediction of Transcriptional Activity of Single Missense Variants in HIV Tat with Deep Learning.

Derbel H, Giacoletto CJ, Benjamin R, Chen G, Schiller MR, Liu Q.

Int J Mol Sci. (2023) 24:6138

https://doi.org/10.3390/ijms24076138; PMID: 37047108 

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Most Synonymous Allelic Variants in HIV Tat are Not Silent.

Giacoletto CJ, Benjamin R, Deng HW, Rotter JI, Schiller MR.

Genomics (2023) 115:110603

https://doi.org/10.1016/j.ygeno.2023.110603; PMID: 36893872 

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Heligenics: Fulfilling the Promise of the Functional Genome to Enable Precision Medicine

Schiller, MR. (2023) March 

Biopharma Dealmakers Issue of Nature. Invited Advertisement

ISSN 2730-6283

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Data Supporting a Saturation Mutagenesis Assay for Tat-driven Transcription with the GigaAssay

Benjamin R, Giacoletto CJ, FitzHugh ZT, Eames D, Buczek L, Wu X, Newsome J, Han MV, Pearson T, Wei Z, Banerjee A, Brown L, Valente LJ, Shen S, Deng HW, Schiller MR.  

Data in Brief (2022) 45:108641

https://doi.org/10.1016/j.dib.2022.108641; PMID: 36426049

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GigaAssay – An Adaptable High-throughput Saturation Mutagenesis Assay Platform

Benjamin R, Giacoletto CJ, FitzHugh ZT, Eames D, Buczek L, Wu X, Newsome J, Han MV, Pearson T, Wei Z, Banerjee A, Brown L, Valente LJ, Shen S, Deng HW, Schiller MR. 

Genomics (2022) 114(4):110439

https://doi.org/10.1016/j.ygeno.2022.110439; PMID: 35905834

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GigaAssay – a high-throughput assay system for molecular functions and cell processes

Schiller MR, Benjamin R, Giacoletto CJ, FitzHugh ZT, Eames D, Buczek L, Wu X, Newsome J, Han MV, Pearson T, Wei Z, Banjeree A, Shen S, Deng HW. Schiller MR

Research Square (2021)

doi: 10.21203/rs.3.rs-708936/v1

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